Marcela Arango Ospina

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Polymer derived bioactive glasses

 

Investigator: Marcela Arango Ospina (PhD Student

Ulrich-Schalk-Straße 3
91058 Erlangen

room 01.117

phone: +49 (0)9131 85-69612

email: marcela.arango@fau.de Marcela Arango Ospina


Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini

 

Bioactive glasses (BGs) are suitable materials for bone regeneration applications. It has been established that the presence of silicon in bioactive glasses has an effect in the osteogenesis process [1]. The intrinsic biological properties of BGs can be improved by the incorporation of therapeutic ions which are aimed to be locally released and provide continuous action and reduced toxicity [2]. Within this project, BGs based on silicon oxycarbide containing therapeutic ions will be synthesized from polymeric precursors following a methodology developed by collaborators at the Department of Disperse Materials, TU Darmstadt [3]. The novel BGs will be characterized in terms of bioactive behavior, ion release kinetics and cytotoxicity. Additionally, silicate bioactive glasses loaded with therapeutic ions will be melted and characterized. A comparison between the two families of BGs will be established. The project is funded by the German Science Foundation (DFG) and involves collaboration with Dr. Isabel Gonzalo-Juan, Dr. habil. Emanuel Ionescu and Prof. Ralf Riedel (TU Darmstadt).

[1] L. L. Hench, Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development, Biomed. Glassess 1 (2015) 1-11.

[2] A. Hoppe, et al., A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials 32 (2011), 2757-2774.

[3] I. Gonzalo-Juan, et al., Synthesis and in vitro activity assessment of novel silicon oxycarbide-based bioactive glasses, Materials, 9(12), (2016) 959.